Well, yes. Technically, Upworlders would be everyone else: Humans with no magical powers. Actually, we call them "mundanes," which isn't a term I like very much, having spent quite a lot of time around them and finding them—for the most part—not at all mundane.

[Magnus passes Reid his cup of tea, plain as requested and brewed to perfection, and immediately flits over to the bookshelf to start looking for his copy.]

Downworlders are warlocks like myself, werewolves, vampires, Seelie, and Shadowhunters. Well, nephilim, but they like Shadowhunters. They hunt and fight demons, hence the rather dramatic name. ...I don't think I brought the guide after all, I'm sorry. I was in something of a hurry when I packed.